More than 20 British tourists are thought to have been on board, according to local media.
State media reported that the bus was carrying 18 Cubans and 22 tourists from the UK, the Netherlands, France, Mexico and Canada when it crashed on a wet road between the eastern cities of Baracoa and Guantanamo.
The driver told Radio Guantanamo he lost control on the wet and winding road.
Thursday’s wreck is the fourth major bus accident in a month.
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