Congestion has built up to J19 Portishead on the northbound side due to the collision, according to traffic monitoring service Inrix.
Traffic is queuing on the M4 Eastbound between Junction 22 M49 and Junction 20 (where it connects with the M5 J15).
Congestion is reported back to the Prince of Wales bridge.
Delays are expected as traffic diverts around the closure of the the M5.
Highways England said: “The M5 in Gloucestershire is closed northbound between J18A (M49) and J17 (Bristol Filton Airport) due to a collision involving 2 HGV’s.
“Road users are advised to exit the M5 at J18A onto the M49 to join the M4 and then re-join the M5.
“Emergency services are at scene.
“Road users are advised to consider alternative routes at this time and allow additional time for their journey.”
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